在許多胰腺導(dǎo)管腺癌（PDAC）細(xì)胞系和組織中檢測(cè)到CDK5或Notch1受體的顯著過(guò)度表達(dá)，其在PDAC的發(fā)展中起關(guān)鍵作用。CDK5通過(guò)磷酸化正向調(diào)節(jié)Notch1功能，進(jìn)而促進(jìn)細(xì)胞增殖和遷移。CDK5和Notch信號(hào)的聯(lián)合抑制可能是治療PDAC的有效策略[6]。
Notch和其他疾病
羅伯特-莫雷諾課題組研究表明，Notch信號(hào)通過(guò)控制GATA2的表達(dá)參與了主動(dòng)脈性腺中腎（AGM）區(qū)域的主動(dòng)脈內(nèi)皮中胚胎造血決定的早期事件[3]。Alagille綜合征（ALGS）是一種罕見的多系統(tǒng)疾病，由JAG1或NOTCH2基因突變引起[7]。賴氨酸特異性脫甲基酶LSD1通過(guò)Jagged-1/Notch信號(hào)通路誘導(dǎo)上皮間質(zhì)轉(zhuǎn)化并促進(jìn)腎纖維化[8]。
相關(guān)產(chǎn)品
Solarbio作為一家全國(guó)的免疫學(xué)產(chǎn)品制造商和小分子化合物供應(yīng)商，擁有多種優(yōu)質(zhì)Notch相關(guān)的抗體和小分子化合物（抑制劑、激活劑和拮抗劑），其小分子化合物產(chǎn)品滿足體內(nèi)外實(shí)驗(yàn)的純度要求。提供液體和固體兩種形式的產(chǎn)品，液體產(chǎn)品多用細(xì)胞級(jí)DMSO配制，DMSO本身具有極強(qiáng)的殺菌力，配制好的溶液可默認(rèn)為無(wú)菌溶液。另外，根據(jù)您的實(shí)驗(yàn)需求，還可提供定制Notch小分子化合物Kit（可任意組合產(chǎn)品、規(guī)格、包裝等）和抗體制備技術(shù)服務(wù)項(xiàng)目，旨在減輕您的實(shí)驗(yàn)操作，為您的科研加油助力。
References
[1]Radtke F,Schweisguth F,etc.The Notch 'gospel'.EMBO Rep.PMID:16299468.
[2]Bray SJ.Notch signalling:a simple pathway becomes complex.Nat Rev Mol Cell Biol.PMID:16921404.
[3]Robert-Moreno A,Espinosa L,etc.RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development.PMID:15689374.
[4]Weng AP,Ferrando AA,etc.Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.Science. PMID:15472075.
[5]Edelmann J,Holzmann K,etc.Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.Haematologica. PMID:31467127
[6]Chu Q,Wang L,Zhang J,etc.CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation.Cancer Med.PMID:33960694
[7]ShenTu Y,Mi X,etc.Alagille syndrome caused by NOTCH2 mutation presented atypical pathological changes.Clin Chim Acta.PMID:34332988.
[8]Zhang H,Xing J,etc.Lysine-specific demethylase 1 induced epithelial-mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway.Hum Exp Toxicol.PMID:34396798.
