ABSTRACT
Apoptosis is the best-characterized form of programmed cell death (PCD) and is of
fundamental importance in tissue homeostasis. In mammalian systems, there are two
major pathways that are involved in the initiation of apoptosis: the “extrinsic” death
receptor pathway and the “intrinsic” mitochondrial pathway. Although these pathways
act independently to initiate the death machinery in some cellular systems, in many cell
types, including numerous tumor cells, there is delicate coordination and cross talk between
the extrinsic and intrinsic pathways, which leads to the activation of the executioner
caspase cascade. Additionally, there appears to be a fine balance between the caspasemediated
arm of death receptor signaling that engages mitochondria and the caspaseindependent
arm that promotes vacuole proliferation in many cells. Here, we review our
current knowledge about the layers of complexity that are posed by the interactions
between death receptor-induced pathways and how they influence mitochondria to regulate
cellular life and death decisions.
Death Receptor Signals to Mitochondria
作者：江蘇凱基生物技術股份有限公司 2008-08-01T00:00 (訪問量:18532)
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