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| 中文名稱 | 卷曲螺旋結構域蛋白106抗體 |
| 別????名 | Ccdc106; Coiled-coil domain-containing protein 106; Protein predicted by clone 23882; ZNF581; CC106_HUMAN.?? |
| 研究領域 | 腫瘤??細胞生物??免疫學??細胞周期蛋白?? |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human,?Mouse,?Rat,? (predicted: Dog,?Cow,?Horse,?) |
| 產品應用 | WB=1:500-2000?ELISA=1:500-1000?IHC-P=1:100-500?IHC-F=1:100-500?IF=1:100-500?（石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分?子?量 | 31kDa |
| 細胞定位 | 細胞核? |
| 性????狀 | Liquid |
| 濃????度 | 1mg/ml |
| 免?疫?原 | KLH conjugated synthetic peptide derived from human CCDC106:201-280/280? |
| 亞????型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲?存?液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Promotes the degradation of p53/TP53 protein and inhibits its transactivity. Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity. Subunit: Interacts with p53/TP53. Subcellular Location: Nucleus. Note=Colocalizes with p53/TP53. SWISS: Q9BWC9 Gene ID: 29903 Database links: Entrez Gene: 29903?Human Entrez Gene: 232821?Mouse Entrez Gene: 499071?Rat Omim: 613478?Human SwissProt: Q9BWC9?Human SwissProt: Q3ULM0?Mouse Unigene: 82482?Human Unigene: 482157?Mouse Unigene: 488775?Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CCDC106通過與p53蛋白相互作用，促進p53蛋白的降解，導致p53功能失活。CCDC106基因很可能是一個癌基因，CCDC106的高表達可能是導致具有野生型p53腫瘤發生的原因之一。 |
| 產品圖片 |  Sample:Jurkat(Human) Cell Lysate at 30 ug Primary: Anti- CCDC106 (bs-5711R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD  Sample:A549(Human) Cell Lysate at 30 ug Primary: Anti- CCDC106 (bs-5711R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD  Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCDC106) Polyclonal Antibody, Unconjugated (bs-5711R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCDC106) Polyclonal Antibody, Unconjugated (bs-5711R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |