Anti-FRS2 (phospho Y436)抗體-抗體-抗體-生物在線
深圳市宇德立生物科技有限公司
Anti-FRS2 (phospho Y436)抗體

Anti-FRS2 (phospho Y436)抗體

商家詢價

產品名稱： Anti-FRS2 (phospho Y436)抗體

英文名稱： FGFR signaling adaptor SNT antibody FGFR signalling adaptor antibody FGFR substrate 2 antibody FGFR-signaling adaptor SNT antibody Fibroblast growth f

產品編號： ab193363

產品價格： null

產品產地： 英國

品牌商標： abcam

更新時間： null

使用范圍：

深圳市宇德立生物科技有限公司
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  • 地址 : 深圳市寶安區西鄉寶民二路賢基大廈4E
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      • 描述
        兔多克隆抗體to FRS2 (phospho Y436)
      • 特異性ab193363 detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.
      • 經測試應用IHC-P,?WBmore details
      • 種屬反應性
        與反應:?Human
        預測可用于:?Mouse
      • 免疫原

        Synthetic peptide corresponding to Human FRS2 (phospho Y436) conjugated to Keyhole Limpet Haemocyanin (KLH).
        Database link:?Q8WU20

      • 陽性對照
        • Human brain tissue, extracts from HuvEc cells or Jurkat cells

      性能

      • 形式Liquid
      • 存放說明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
      • 存儲溶液pH: 7.40
        Preservative: 0.02% Sodium azide
        Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride

        PBS is without Mg2+?and Ca2+
      • ?
      • 純度Immunogen affinity purified
      • 純化說明ab193363 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
      • 克隆多克隆
      • 同種型IgG
      • 研究領域

      應用

      Our?Abpromise guarantee?covers the use of?ab193363?in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      應用 Abreviews 說明
      IHC-P ? 1/50 - 1/100.
      WB ? 1/500 - 1/1000. Predicted molecular weight: 65 kDa.

      靶標

      • 功能Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
      • 組織特異性Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
      • 序列相似性Contains 1 IRS-type PTB domain.
      • 翻譯后修飾Phosphorylated on tyrosine residues upon stimulation by NGF.
        Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
      • 細胞定位Endomembrane system. Cytoplasmic, membrane-bound.

      • Anti-FRS2 (phospho Y436) antibody 圖像

        • Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling FRS2 with ab193363 at a 1/50 dilution. Right panel has been pre-incubated with blocking peptide.

        • All lanes :?Anti-FRS2 (phospho Y436) antibody (ab193363) at 1/500 dilution

          Lane 1 :?HuvEc extract with Antigen specific peptide
          Lane 2 :?Huvec extract
          Lane 3 :?Jurkat extract


          Predicted band size :?65 kDa