TLR4 polyclonal antibody
產(chǎn)品名稱： TLR4 polyclonal antibody
英文名稱： TLR4 polyclonal antibody
產(chǎn)品編號(hào)： PAB15432
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 臺(tái)灣
品牌商標(biāo)： Abnova
更新時(shí)間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺(tái)灣臺(tái)北市內(nèi)湖區(qū)洲子街 108 號(hào) 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺(tái)灣
- 電話 : +886-920**1152 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
- Immunogen:
- A synthetic peptide corresponding to amino acids 420-435 of human TLR4.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- Detects ~75-80KDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.05% BSA, sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-3 ug/mL)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B.Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2163-7.
- 2.
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.Immunity. 1999 Oct;11(4):443-51.
- 3.
- The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).
Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A.J Exp Med. 1998 Jun 15;187(12):2097-101.
- Entrez GeneID:
- 7099
- Gene Name:
- TLR4
- Gene Alias:
- ARMD10,CD284,TOLL,hToll
- Gene Description:
- toll-like receptor 4
- Omim ID:
- 603030
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022807,homolog of Drosophila toll
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