5-lipoxygenase Antibody
產品名稱： 5-lipoxygenase Antibody
英文名稱： 5-lipoxygenase Antibody
產品編號： 251179
產品價格： null
產品產地： 美國
品牌商標： Abbiotec
更新時間： null
使用范圍： E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
深圳市豪地華拓生物科技有限公司
- 聯系人 :
- 地址 : 深圳市南山創業路中興城5棟518
- 郵編 : 518054
- 所在區域 : 廣東
- 電話 : 132****4656 點擊查看
- 傳真 : 點擊查看
- 郵箱 : order@otwobiotech.com
Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and plays a role in inflammatory processes. 5-lipoxygenase is expressed specifically in bone marrow-derived cells. This enzyme catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(s)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma. These mutations are also associated with atherosclerosis and several cancers.