14-3-3 Theta重組兔單克隆抗體
產(chǎn)品名稱： 14-3-3 Theta重組兔單克隆抗體
英文名稱： 14-3-3 sigma (2E12) 
產(chǎn)品編號(hào)： 52005
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 上海
品牌商標(biāo)： 雅吉
更新時(shí)間： null
使用范圍： WB, IF, ICC
上海雅吉生物科技有限公司
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英文名稱 14-3-3 sigma (2E12) 中文名稱 14-3-3 sigm重組兔單克隆抗體 別????名 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS.?? 研究領(lǐng)域 細(xì)胞生物??染色質(zhì)和核信號(hào)??神經(jīng)生物學(xué)??信號(hào)轉(zhuǎn)導(dǎo)??干細(xì)胞??轉(zhuǎn)錄調(diào)節(jié)因子?? 抗體來(lái)源 Rabbit 克隆類型 Monoclonal 克?隆?號(hào) 2E12 交叉反應(yīng) (predicted: Human,?) 產(chǎn)品應(yīng)用 WB=1:500-1000?IHC-P=1:50-200?IHC-F=1:50-200?ICC=1:50-200?IF=1:50-200?（石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分?子?量 28kDa 細(xì)胞定位 細(xì)胞核?細(xì)胞漿?分泌型蛋白? 性????狀 Liquid 濃????度 1mg/ml 免?疫?原 recombinant human 14-3-3 sigma full length protein:? 亞????型 IgG 純化方法 affinity purified by Protein A 儲(chǔ)?存?液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed 產(chǎn)品介紹 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibit