MEK3 Rabbit pAb (APR27634N)
產(chǎn)品名稱： MEK3 Rabbit pAb (APR27634N)
英文名稱： MEK3 Rabbit pAb (APR27634N)
產(chǎn)品編號(hào)： APR27634N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍： WB (Oryza sativa, Mus musculus) IP (Oryza sativa)
生物谷
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- 郵編 : 100176
- 所在區(qū)域 : 上海
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分子量：Calculated MW: 36kDa/39kDa Observed MW: 39kDa 稀釋方法：WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 總結(jié)：The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.