• 形式Liquid
• 存放說明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存儲溶液Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• 濃度Batch dependent within range:?100 μg 濃度為 0.9 - 1 mg/ml?
  

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• 純度Immunogen affinity purified
• 克隆多克隆
• 同種型IgG
• 研究領域
  • Neuroscience
  ?
  • Cell Type Marker
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  • Neural Stem Cell marker

  • Signal Transduction
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  • Cytoskeleton / ECM
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  • Cytoskeleton
  • Intermediate Filaments
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  • Class III
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  • Vimentin

  • Neuroscience
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  • Neurology process
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  • Neurogenesis

  • Stem Cells
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  • Lineage Markers
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  • Endoderm

  • Stem Cells
  ?
  • Neural Stem Cells
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  • Intracellular

  • Cancer
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  • Tumor biomarkers
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  • Other

  • Neuroscience
  ?
  • Neurology process
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  • Neuroregeneration
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  • Neuroregeneration

  • Developmental Biology
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  • Lineage specification
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  • Ectoderm

應用

靶標

• 功能Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
  Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
• 組織特異性Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
• 疾病相關Cataract 30
• 序列相似性Belongs to the intermediate filament family.
• 結構域The central alpha-helical coiled-coil rod region mediates elementary homodimerization.
  The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
• 翻譯后修飾Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
  O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
  S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
• 細胞定位Cytoplasm.
• Information by UniProt
• 數據庫鏈接
  • Entrez Gene: 420519?Chicken
  • Entrez Gene: 493952?Chimpanzee
  • Entrez Gene: 280955?Cow
  • Entrez Gene: 7431?Human
  • Entrez Gene: 22352?Mouse
  • Entrez Gene: 407747?Pig
  • Entrez Gene: 81818?Rat
  • Omim: 193060?Human

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