Anti-Vimentin抗體- Cytoskeleton Marker-抗體-抗體-生物在線(xiàn)

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深圳市宇德立生物科技有限公司
Anti-Vimentin抗體- Cytoskeleton Marker

Anti-Vimentin抗體- Cytoskeleton Marker

商家詢(xún)價(jià)

產(chǎn)品名稱(chēng)： Anti-Vimentin抗體- Cytoskeleton Marker

英文名稱(chēng)： ab45939

產(chǎn)品編號(hào)： ab45939

產(chǎn)品價(jià)格： null

產(chǎn)品產(chǎn)地： 英國(guó)

品牌商標(biāo)： abcam

更新時(shí)間： null

使用范圍：

深圳市宇德立生物科技有限公司
  • 聯(lián)系人 :
  • 地址 : 深圳市寶安區(qū)西鄉(xiāng)寶民二路賢基大廈4E
  • 郵編 :
  • 所在區(qū)域 : 廣東
  • 電話(huà) : 133****4454 點(diǎn)擊查看
  • 傳真 : 點(diǎn)擊查看
  • 郵箱 : 1484332550@qq.com

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應(yīng)用

Our?Abpromise guarantee?covers the use of?ab45939?in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

應(yīng)用 Abreviews 說(shuō)明
IHC-P ? Use a concentration of 0.1 μg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB ? Use a concentration of 1 μg/ml. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).Can be blocked with?Vimentin peptide (ab46156).
ICC/IF ? Use a concentration of 1 μg/ml.
Flow Cyt ? Use 0.01-0.1μg for 106?cells.
IHC-Fr ? 1/50.

靶標(biāo)

  • 功能Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
    Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
  • 組織特異性Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
  • 疾病相關(guān)Cataract 30
  • 序列相似性Belongs to the intermediate filament family.
  • 結(jié)構(gòu)域The central alpha-helical coiled-coil rod region mediates elementary homodimerization.
    The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • 翻譯后修飾Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
    O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
    S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • 細(xì)胞定位Cytoplasm.
  • Information by UniProt
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