Phospho-CBL-Y700 Rabbit pAb (AMR01063N)
產(chǎn)品名稱(chēng)： Phospho-CBL-Y700 Rabbit pAb (AMR01063N)
英文名稱(chēng)： Phospho-CBL-Y700 Rabbit pAb (AMR01063N)
產(chǎn)品編號(hào)： AMR01063N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
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分子量：Calculated MW: 99kDa Observed MW: 120kDa 細(xì)胞定位：Cell membrane, Cytoplasm 稀釋方法：WB 1:500 - 1:2000 總結(jié)：This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.