CEP131 Rabbit pAb (APR23864N)
產(chǎn)品名稱： CEP131 Rabbit pAb (APR23864N)
英文名稱： CEP131 Rabbit pAb (APR23864N)
產(chǎn)品編號(hào)： APR23864N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
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- 所在區(qū)域 : 上海
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分子量：Calculated MW: 117kDa/121kDa/122kDa Observed MW: 145kDa 稀釋方法：WB 1:500 - 1:2000 總結(jié)：Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT and/or intramanchette (IMT trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication (By similarity. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.