Thapsigargin (CAS: 67526-95-8)
產品名稱： Thapsigargin (CAS: 67526-95-8)
英文名稱： Thapsigargin
產品編號： SIH-399-5MG
產品價格： 0
產品產地： 加拿大
品牌商標： StressMarq
更新時間： null
使用范圍： null
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Thapsigargin is a cell-permeable inhibitor of the sarco-endoplasmatic reticulum Ca2+-ATPase (SERCA). This inhibition causes the release of intracellular Ca2+ stores. Thapsigargin also inhibits autophagy. This is due to the induction of and an ER stress response, which causes downstream effects that include an accumulation of autophagosomes in the cytosol. These intermediate structures never mature into amphisomes and autolysosomes, and the autophagy process cannot be completed.