Anti-Lin28B Polyclonal Antibody
產(chǎn)品名稱： Anti-Lin28B Polyclonal Antibody
英文名稱： Lin28B;CSDD 2;CSDD2;FLJ16517;Lin 28 homolog B (C. elegans);Lin 28.2;Lin-28B;LIN28B;LN28B_HUMAN;Protein lin-28 homolog B
產(chǎn)品編號(hào)： K009663P
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 北京
品牌商標(biāo)：
更新時(shí)間： 2026-07-02T10:39:01
使用范圍： WB ELISA IHC-P IHC-F IF
北京索萊寶科技有限公司
- 聯(lián)系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經(jīng)濟(jì)技術(shù)開發(fā)區(qū)環(huán)科中路16號(hào)26幢3層301
- 郵編 :
- 所在區(qū)域 : 北京
- 電話 : 181****6239 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : 3193328036@qq.com
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Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.