EDNRB polyclonal antibody
產(chǎn)品名稱： EDNRB polyclonal antibody
英文名稱： EDNRB polyclonal antibody
產(chǎn)品編號： PAB7971
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內(nèi)湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.
- Immunogen:
- A synthetic peptide corresponding to amino acids at middle region region of human EDNRB.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 49.6
- Reactivity:
- Human
- Specificity:
- The sequence identical to the related rat sequence.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The temporal requirement for endothelin receptor-B signalling during neural crest development.
Shin MK, Levorse JM, Ingram RS, Tilghman SM.Nature. 1999 Dec 2;402(6761):496-501.
- 2.
- A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease.
Yang GC, Croaker D, Zhang AL, Manglick P, Cartmill T, Cass D.Hum Mol Genet. 1998 Jun;7(6):1047-52.
- 3.
- Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.
Gariepy CE, Cass DT, Yanagisawa M.Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):867-72.
- Entrez GeneID:
- 1910
- Gene Name:
- EDNRB
- Gene Alias:
- ABCDS,ETB,ETBR,ETRB,HSCR,HSCR2
- Gene Description:
- endothelin receptor type B
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
- Other Designations:
- OTTHUMP00000178736,endothelin receptor non-selective type
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