產品詳細描述

詳細配制內容及參數資料

1.1 特點

l可以做更準確的藥代動力學和毒物學的研究

l更清楚準確的反應了體內血腦屏障的特性

l模擬重要的內皮細胞與星形膠質細胞之間的作用

l用電力方法檢測了血腦屏障的完整性

l可以用真實的細胞做實驗

l比現存的靜態模型更能形成緊密的連接

l降低藥物研發的成本

1.2 配置及參數資料

TEER檢測系統CARTRIDGE底板

4個DIV-BBB盒子檢測軟件電纜線

DIV-BBB?管腔

經毛細管孔徑：0.2um

中空纖維數量：19

腔內總體積：0.0123in³= 0.202cm³

腔內表面積：2.09 in³= 13.5cm²

腔外體積：0.070 in³= 1.15cm³

腔外中空纖維總面積：3.50 in³= 22.6cm²

TEER檢測系統

TEER檢測系統為研發人員提供了一個快速、簡便地評估血腦屏障完整性方法，此外，電阻抗值（＞1000 Ω-cm²）也非常接近體內數值。TEER檢測系統同時配帶了所需檢測軟件、電線和襯板，可供4個DIV-BBB管腔同時使用。其中檢測軟件可以自定義設置泵的流速、頻率、波形等參數。其它特性及優點見下表：

脈動泵

脈搏率和作用周期完全模擬體內血液動力學設計，貼近體內環境，試驗準確，脈搏率可設置在30-120/分范圍內。其特性和優點見下：

電腦配置最低要求

?IBM兼容電腦，400MHz或者更快

?Window 2000或者更高系統

?128MB存儲器（推薦256MB）

?

About Flocel

Every year millions of dollars are spent by pharmaceutical companies to develop and test drugs using in vitro models of the Blood-Brain Barrier (BBB). Many of these cases end up not working in vivo.CleveMedhas licensed technology fromThe Cleveland Clinic Foundation and formed Flocel Inc, to manufacture a practical in vitro model that more accurately reflects the BBB characteristics. Flocel's dynamic in vitro blood-brain barrier (DIV-BBB) technology helps researchers in the United States and Europe conduct in vitro studies.

Flocel also offers atesting service for BBB permeability compounds. To learn more about our testing services, clickhere.

Introduction to the Blood-Brain Barrier

TThe blood-brain barrier (BBB) explains why certain substances circulating in the blood are able to get into the brain and others do not. The BBB is formed by brain capillaries that look like simple tubes of endothelial cells. Experimental and clinical evidence suggests that the BBB maintains the chemical environment for neuronal function and protects the brain from harmful substances. The blood-brain barrier is therefore crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases, and issues related to bio-defense. We have developed a practical in vitro model that accurately reflects BBB characteristics.

Benefits of Flocel’s in vitro BBB Model

In contrast to other available models of the blood-brain barrier, Flocel's Dynamic In vitro Blood-Brain Barrier (DIV-BBB) respects the anatomical aspects of the in situ endothelial cell-astrocyte interactions and replicates the physiological levels of shear stress to which in situ endothelial cells are exposed. The DIV-BBB allows formation of physiological transendothelial resistance, and formation of gap junctions that can be easily visualized at the electron microscope or determined experimentally with the use of tracers.

Mission

Flocel Inc. is a biotechnology company dedicated to innovation towards helping the research community better conduct and advance in vitro studies.

In vitro BBB Technology

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