Size??100ug
Cat code??200729
Species Cross-reactivity??H
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??null
Isotype??IgG1
Molecular Weight??56kDa
Sensitivity??This antibody detects endogenous levels of TXNRD2 and does not cross-react with related proteins.
Immunogen??Purified recombinant human TXNRD2 protein fragments expressed in E.coli.
UniProt Number??Q9NNW7
GeneBank ID??NM_006440.3
Subcellular location??Mitochondrion
Formulation??ascites
Altername??Selenoprotein Z;TR-beta;Thioredoxin reductase TR3
Gene_symbol??TR; TR3; SELZ; TRXR2; TR-BETA
Summary??Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
UniPort summary  Function?? Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
 
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Application Images :??

Western blot detection of TXNRD2 in A431,U251，U2OS,LNCAP&Hela cell lysates and  using TXNRD2 antibody (1:1000 diluted). Predicted band size: 56KDa Observed band size: 56KDa