IHC analysis of Slo using SMC-383, tested on mouse cerebellum tissues.? Nuclear staining of oligodendrocytes and microglial cells of the white matter. Neurons are negative.

The Slo1 channel is a novel potassium channel that is regulated by both Ca2+ and voltage. It is a homolog to the pH and voltage-regulated Slo3 channel. Four distinct subunits composing the KCNMB family are known to regulate the function and expression of Slo1 channels (3). Slo1 has been shown to be involved in neurotransmitter release and etheanol response. It has been reported that SLO1 also has a critical role is muscles- the inactivation of the slo-1 gene in muscles leased to phenotypes similar to those cause by mutations of the dystrophin homologue dys-1 (4).

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. www.iochannels.org
3. Yang, C.T., Zeng X.H., Xia X.M., and Lingle C.J. (2009) PloS One. 4(7): e6135.
4. Carre-Pierrat M., et al. (2006) J Mol Biol. 358(2): 387-395.