重組SARS-CoV-2棘突蛋白(S1亞基)
產品名稱： 重組SARS-CoV-2棘突蛋白(S1亞基)
英文名稱： Recombinant SARS-CoV-2  Spike Protein S1
產品編號： GMP-TL761
產品價格：
產品產地： China
品牌商標： 同立海源生物
更新時間： 2023-08-28T14:36:51
使用范圍： null
| 規格 | 價格 |
| 50μg | 2500.0 |
- 聯系人 : 崔女士
- 地址 : 北京市大興區中關村科技園區大興生物醫藥產業基地華佗路50號院13號樓
- 郵編 : 100085
- 所在區域 : 北京
- 電話 : 186****3653 點擊查看
- 傳真 : 點擊查看
- 郵箱 : cuilimei@seafrom.cn
重組SARS-CoV-2棘突蛋白（S1亞基），GMP級
英文名稱：Recombinant SARS-CoV-2 Spike Protein(S1 Subunit)
產品貨號：GMP-TL761
產品描述（Description）
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-Cov-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
分子別名（Synonym）
2019-nCoV coronavirus spike Protein; 2019-nCoV cov spike Protein; ncov RBD Protein, 2019-nCoV; 2019-nCoV ncov s1 Protein; 2019-nCoV NCP-CoV s1 Protein;
表達宿主（Expression host）
HEK293細胞
蛋白序列（Protein Sequence）
DNA序列編碼重組SARS-CoV-2 (2019-nCoV) S1蛋白表達帶有His標簽在C末端
分子量（Molecular Weight）
重組SARS-CoV-2 (2019-nCoV) S1蛋白包含698個氨基酸，預測的理論分子量為78.3kD
純度（Purity）
＞90% 采用SDS-PAGE凝膠分析
內毒素（Endotoxin）
≤0.01EU/ug（凝膠法）
圖片（Images）
穩定性（Stability）
1、凍干的樣本可在4℃保存24個月，溶解后的液體可于-20℃保存6-12個月，并且避免反復凍融。
2、液體樣本在-20~-80℃保存12個月，融化后需要進行分裝保存于-20℃保存6-12個月，避免反復凍融。
組成（Component）
1．含有 6%甘露醇和 6%海藻糖的無菌 PBS（pH7.4）的凍干粉。
2．0.2 μM 無菌過濾的 PBS,pH 7.4 的液體。
注意：For research and manufacturing use.