Anti-VEGFA Polyclonal Antibody
品牌：solarbio | 貨號：K001655P
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商品品牌：
規格
基本售價：
選擇規格
K001655P-50ul
solarbio
50ul
960.00元
K001655P-100ul
solarbio
100ul
1600.00元

英文名稱
Anti-VEGFA Polyclonal Antibody
別名
MVCD1;VEGF;VPF
應用
WB IF IP
稀釋比例
WB 1:500-2000. IF 1:50-200. IP 1:50-100.
交叉反應
Human Mouse Rat
蛋白分子量
27kDa
Gene ID
7422
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
A synthetic peptide of human VEGFA
性狀
液體
Public Immunogen Range
A synthetic peptide of human VEGFA
Subcellular Locations
Secreted
Swiss Prot
P15692
克隆類型
Polyclonal Antibody
背景資料
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.