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Human Growth Factors & Cytokines
            
Recombinant Human IL-1beta
            

            

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Synonyms :
                        
                        

                        
Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
                        
                    
                    

                        

                        
Description :
                        
                        

                        
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
200-01B
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
                        
                    
                    

                        

                        
Selected References :
                        
                        

                        
Selected List of References Citing This PeproTech Product
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
IL-1+AND+beta
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
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Size A
                                    
2μg
                                    
$80?
                                    
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Size B
                                    
10μg
                                    
$195?
                                    
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Size C
                                    
1mg
                                    
$3900?
                                    
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Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
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Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures. 
                        
                    
                
            
            

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