RASD2 Rabbit pAb (APR23674N)
產(chǎn)品名稱： RASD2 Rabbit pAb (APR23674N)
英文名稱： RASD2 Rabbit pAb (APR23674N)
產(chǎn)品編號： APR23674N
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標： Leading Biology
更新時間： null
使用范圍：
分子量：Calculated MW: 30kDa Observed MW: 30kDa 稀釋方法：WB 1:500 - 1:2000 總結：This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.