NaPi2b,also named SLC34A2, is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans. Although NaPi2b is widely expressed in normal tissues, its overexpression has been demonstrated in ovarian, lung, and other cancers. NaPi2b may comprise of never been considered, established, continuous, and discontinuous epitopes and therefore represents a new family of potential cell surface markers and targets for the immunotherapy of several types of cancers.