Recombinant Human BMP-4
 
Catalog Number:
AF-120-05ET
Synonyms:
BMP-2B, DVR4
Description:
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor. Manufactured using all non-animal reagents.
AA Sequence:
KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
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Cross Reactivity:
Mouse
Research Interests:
Angiogenesis/ Cardiovascular
Apoptosis
Bone, Skeletal, Cartilage
Proliferation
Stem Cells & Differentiation
TGF-β Superfamily
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.