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Murine & Rat Growth Factors & Cytokines
Recombinant Murine APRIL





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		Synonyms :
A Proliferating-inducing Ligand, TNFSF13, TRDL-1 alpha



		Description :
APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues.  APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA.  APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells.  Like BAFF, APRIL also stimulates the proliferation of B and T cells.  The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein.  All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor.  Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.



		Catalog #:
315-13



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE and HPLC analyses.  Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Measured by its ability to induce cell proliferation of activated T cells.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL 



		PubMed Link :
April+AND+TNF+AND+mouse


Country of Origin :
USA
















        Size A
5μg
$80?
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        Size B
20μg
$195?
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        Size C
1mg
$3000?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.