There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF hand containing
proteins required for the traffic of channel forming
Kv4 K+ subunits to the plasma membrane (3).
KChiP3 is also known as calsenilin and as the transcription
factor, downstream regulatory element antagonist
modulator (DREAM), which regulates a number of genes
including prodynorphon. They are highly expressed in the
hippocampus. Through its various functions, it may play a
role in the regulation of synaptic plasticity, learning and
memory (4).