Size??100ug
Cat code??200668
Species Cross-reactivity??H,M,R
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??64kDa
Sensitivity??This antibody detects endogenous levels of ATIC and does not cross-react with related proteins.
Immunogen??Purified recombinant human ATIC protein fragments expressed in E.coli.
UniProt Number??P31939
GeneBank ID??NM_004044.6
Subcellular location??null
Formulation??Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername??5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase,AICAR transformylase2.IMP cyclohydrolase,ATIC,IMP synthase Inosinicase
Gene_symbol??PURH; AICAR; AICARFT; IMPCHASE 
Summary??This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
UniPort summary  Function??Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
Application Images :??
Western blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).
Predicted band size:64KDa.
Observed band size:64KDa