PeproTech小鼠抗大鼠CD80 (B7-1) PE
產品名稱： PeproTech小鼠抗大鼠CD80 (B7-1) PE
英文名稱： Anti-Rat CD80 (B7-1) PE
產品編號： 02913-60-100
產品價格： null
產品產地： USA
品牌商標： peperotech(BioGems)
更新時間： null
使用范圍： 流式
美國PeproTech(派普泰克)公司中國代表處
- 聯系人 :
- 地址 :  江蘇省蘇州市工業園區星湖街218號A1北座4樓L03
- 郵編 : 215123
- 所在區域 : 江蘇
- 電話 : 點擊查看
- 傳真 : 點擊查看
- 郵箱 : peprotech.infochina@thermofisher.com
The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The 3H5 antibody block the binding of CD80 to its ligands.