重組人 MUC-1蛋白（Recombinant Human MUC-1 Protein），GMP級

產品貨號：GMP-TL689

產品描述（Description）

Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this

protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack.

分子別名（Synonym）

Mucin 1、MUC1、CD227、EMA、H23AG、KL-6、MAM6、MUC-1/SEC、MUC-1/X、MUC1/ZD、PEM、PEMT、PUM、CA 15-3、Episialin

表達宿主（Expression host）

HEK293 細胞

來源（Source）

Human

蛋白序列（Protein Sequence）

DNA 序列編碼人 MUC-1（UniProtKB/Swiss-Prot: P15941）表達帶有 Fc 標簽在 C 末端

分子量（Molecular Weight）

重組人 MUC-1 蛋白包含 366 個氨基酸，預測理論分子量為 38.4 kD

純度（Purity）

≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析

內毒素（Endotoxin）

＜0.1EU/ug

使用說明（Instructions）

穩定性和儲存：凍干的樣本的可以在4℃保存24個月，溶解后的液體可以于-20℃保存6~12個月，并且避免反復凍融

組成（Component）

含有6%甘露醇的無菌PBS（PH 7.4）的凍干粉

參考文獻

1、 Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines Feifei Pu, Fengxia Chen, Zhicai Zhang, Jing Feng, Ping Xia Future Sci OA. 2018 Jun; 4(5): FSO298. Published online 2018 Mar 15. doi: 10.4155/fsoa-2017-0121

2、Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung CancerChih-Hsi Scott Kuo, Chien-Ying Liu, Stelios Pavlidis, Yu-Lun Lo, Yen-Wen Wang, Chih-Hung Chen, How-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Tsai-Yu Wang, Kang-Yun Lee, Yi-Ke Guo, Tzu-Hao Wang, Cheng-Ta Yang Front Immunol. 2018; 9: 232. Published online 2018 Feb 12. doi: 10.3389/fimmu.2018.00232

注意：For research and manufacturing use.