ATRX (Human) Recombinant Protein (P01)
產品名稱： ATRX (Human) Recombinant Protein (P01)
英文名稱： ATRX (Human) Recombinant Protein (P01)
產品編號： H00000546-P01
產品價格： 0
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍： null
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human ATRX full-length ORF ( AAH02521, 1 a.a. - 90 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVNKND
- Theoretical MW (kDa):
- 35.53
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 546
- GeneBank Accession#:
- BC002521
- Protein Accession#:
- AAH02521
- Gene Name:
- ATRX
- Gene Alias:
- ATR2,MGC2094,MRXHF1,RAD54,RAD54L,SFM1,SHS,XH2,XNP,ZNF-HX
- Gene Description:
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- DNA dependent ATPase and helicase,OTTHUMP00000024265,OTTHUMP00000062079,X-linked nuclear protein,Zinc finger helicase,helicase 2, X-linked,transcriptional regulator ATRX
- Related Disease