Size??100ug
Cat code??220007
Species Cross-reactivity??H,M,R,Mk
Key Application??WB,ICC
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??
Isotype??IgG1
Molecular Weight??90kDa
Sensitivity??This antibody detects endogenous levels of HSP90AB1 and does not cross-react with related proteins.
Immunogen??Purified recombinant fragment of human HSP90AB1 expressed in E. Coli.
UniProt Number??P08238
GeneBank ID??NM_007355
Subcellular location??Cytoplasm.Melanosome.
Formulation??Ascitic fluid containing 0.03% sodium azide.
Altername??D6S182;FLJ26984;FLJ31884;heat shock 90kDa protein 1 alpha;Heat shock protein 90kDa alpha cytosolic class A member 1;Heat shock protein 90kDa alpha cytosolic class B member 1;Heat shock protein HSP 90 alpha;Heat shock protein HSP 90 beta;HSP 84;HSP 86;Hsp 90;HSP84;HSP86;Hsp89;Hsp90;HSP90 Beta;HSP90A;HSP90AA1;HSP90AB1;HSP90B;HSP90N;HSPC1;HSPC2;HSPCA;HSPCAL1;HSPCAL4;HSPCB;HSPN;LAP2; Lipopolysaccharide associated protein2;LPS associated protein 2;NY REN 38 antigen.
Gene_symbol??HSP84;HSPC2;HSPCB;D6S182;HSP90B.
Summary??This gene encodes a member of the heat shock protein 90 family;these proteins are involved in signal transduction,protein folding and degradation and morphological evolution.This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation.Alternative splicing results in multiple transcript variants.Pseudogenes have been identified on multiple chromosomes.[provided by RefSeq,Dec 2012]
UniPort summary  Function??Molecular chaperone that promotes the maturation,structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.Undergoes a functional cycle that is linked to its ATPase activity.This cycle probably induces conformational changes in the client proteins,thereby causing their activation.Interacts dynamically with various co-chaperones that modulate its substrate recognition,ATPase cycle and chaperone function.
Application Images :??
Western blot detection of HSP90AB1 antibody in Hela,PC-12,COS7,C6 and 3T3 cell lysates using HSP90AB1 antibody (1:500 diluted).Predicted band size:90KDa.Observed band size:90KDa.
Immunocytochemistry staining of HeLa cells using anti-HSP90AB1 antibody (dilution 1:100).