• 特異性Please note: Low dilutions of this antibody can cause high background. Please use as high a dilution as possible. Optimal working dilutions are batch dependent.
• 經測試應用WB,?ICC,?ICC/IF,?IHC-FrFl,?IHC-FoFr,?IHC-Fr,?IHC-Pmore details
• 種屬反應性
  與反應:?Mouse, Rat, Chicken, Cat, Human, Cynomolgus Monkey, Quail, Rhesus monkey
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human Doublecortin.

  參閱Abcam的專有抗源政策

  ?

  (Peptide available as?ab19804.)

• 陽性對照
  • This antibody gave a positive signal in Brain (Mouse) Tissue Lysate - normal tissue, 0 days old

性能

• 形式Liquid
• 存放說明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存儲溶液Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• 濃度Batch dependent within range:?50 μg 濃度為 0.9 - 1 mg/ml?
  

  查找您批次的濃度
• 純度Immunogen affinity purified
• 克隆多克隆
• 同種型IgG
• 研究領域
  • Neuroscience
  ?
  • Cell Adhesion Proteins
  ?
  • Cytoskeletal Proteins
  ?
  • Microtubules

  • Neuroscience
  ?
  • Cell Type Marker
  ?
  • Neuron marker
  ?
  • Soma marker

  • Neuroscience
  ?
  • Cell Type Marker
  ?
  • Neuron marker
  ?
  • Growth Cone

  • Tags & Cell Markers
  ?
  • Cell Type Markers
  ?
  • Neuroscience Markers
  ?
  • Neuronal

應用

靶標

• 功能Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.
• 組織特異性Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
• 疾病相關Defects in DCX are the cause of lissencephaly X-linked type 1 (LISX1) [MIM:300067]; also called X-LIS or LIS. LISX1 is a classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'.
  Defects in DCX are the cause of subcortical band heterotopia X-linked (SBHX) [MIM:300067]; also known as double cortex or subcortical laminar heterotopia (SCLH). SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
  Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).
• 序列相似性Contains 2 doublecortin domains.
• 細胞定位Cytoplasm.
• Information by UniProt
• 數據庫鏈接
  • Entrez Gene: 1641?Human
  • Entrez Gene: 13193?Mouse
  • Entrez Gene: 84394?Rat
  • Omim: 300121?Human
  • SwissProt: O43602?Human
  • SwissProt: O88809?Mouse
  • SwissProt: Q9ESI7?Rat
  • Unigene: 34780?Human

  TUNEology 波長可調檢測卡盒-->