Metabolic competency delivered in 3D

Are you looking for a more economical, more predictive?in vitro?model system for toxicity/DMPK, efficacy?or disease modeling?? InSphero delivers assay-ready 3D InSightTM?Liver Microtissues in 96-well format?conveniently to your lab.??Upgrade your toxicity and safety assessment workflow with?our long-lived?hepatocyte and hepatocyte/non-parenchymal cell (NPC) co-culture microtissues.? Our 3D models go beyond the limitations of traditional 2D monolayer cell culture to provide:

• Viability >4 weeks
• Stable, inducible CYP expression
• Organotypic cytoarchitecture, including BSEP expression and functional bile salt secretion

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Unparalleled convenience

InSphero?3D culture technology not only?brings far greater assurance to in-house compound de-risking, but also offers?the convenience of:

• Fixed production schedule for routine experimental timelines
• Reproducible manufacturing QC'd to ISO 9001:2008 standards to ensure continuity
• Convenient delivery in GravityTRAPTM?assay plates, ready for dosing
• Multiple donor profiles available to meet specific needs

?Need results faster?? Let our 3D experts do the screening for you with 3D InSightTM?Toxicology Services.?

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3D InSightTM?Liver Microtissues

InSphero?liver microtissues are helping to define a new standard for?in vitro?liver models.? Learn more in our 3D InSightTM?Liver Microtissue?brochure.

Our 3D Liver Microtissue pipeline

The following 3D InSight? Microtissues are in development.?Please contact us for more information about availability and beta testing opportunities.

• Dog Liver Microtissues (beta test now)
• Minipig Liver Microtissues (beta test now)
• HepaRG Liver Microtissues (beta test now)
• Mouse Liver Microtissues
• Human Liver Microtissues from iPSC derived hepatocytes