美國Peprotech 100-11 Recombinant Human IGF-1
產品名稱： 美國Peprotech 100-11 Recombinant Human IGF-1
英文名稱： Recombinant Human IGF-1
產品編號： 100-11
產品價格： 0
產品產地： 美國
品牌商標： Peprotech
更新時間： null
使用范圍： null
北京雅安達生物技術有限公司
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Recombinant Human IGF-I
Catalog Number:
100-11
Synonyms:
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description:
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
AA Sequence:
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Cross Reactivity:
Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A
Research Interests:
 |
Angiogenesis/ Cardiovascular |  |
Bone, Skeletal, Cartilage |
 |
Diabetes / Weight Regulation |  |
Inflammation |
 |
Proliferation |  |
Wound Healing |
Country of Origin:
USA