Gliadin Peptide (4F3) Antibody
產品名稱： Gliadin Peptide (4F3) Antibody
英文名稱： Gliadin Peptide (4F3) Antibody
產品編號： 250438
產品價格： null
產品產地： 美國
品牌商標： Abbiotec
更新時間： null
使用范圍： Product Cat. No. 250438 reacts equally strong in ELISA with the deamidated gliadin-related peptide (KLQPFPQPELPYPQPQ) an
深圳市豪地華拓生物科技有限公司
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- 郵編 : 518054
- 所在區域 : 廣東
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- 郵箱 : order@otwobiotech.com
Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody cross-reacts fully with the non-deamidated peptide KLQPFPQPQLPYPQPQ