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Human Growth Factors & Cytokines
Recombinant Human Resistin





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		Synonyms :
FIZZ3, Adipose tissue-specific secretory factor, ADSF



		Description :
Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM.  The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C.  Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown.  Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes.  Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.  Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.



		Catalog #:
450-19



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by its ability to stimulate lipolysis in cultured human adipocytes. (Ort, T. et al. Endocrinology; 46(5):2200-9)


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP 



		PubMed Link :
Resistin+AND+human


Country of Origin :
USA
















        Size A
5μg
$80?
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        Size B
25μg
$195?
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        Size C
1mg
$5200?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.