Size??100ul
Cat code??220034
Species Cross-reactivity??H, R, M
Key Application??WB
Host??Mouse
Clone Number??5H7-D5-E2
Antibody type??Monoclonal antibody
Purified method??
Isotype??IgG1
Molecular Weight??30kDa
Sensitivity??The antibody detects endogenous level of PHB protein.
Immunogen??Purified recombinant fragment of human PHB expressed in E. Coli.
UniProt Number??P35232
GeneBank ID??NM_002634.2
Subcellular location??Mitochondrion inner membrane
Formulation??Ascitic fluid containing 0.03% sodium azide.
Altername??PHB; PHB_HUMAN; PHB1; Prohibitin;
Gene_symbol??PHB1
Summary??This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3′ UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniPort summary  Function??Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Application Images :??
Western blot detection of PHB antibody in C6, COS7, 3T3 and Hela cell lysates using PHB antibody (dilution 1:1000).Predicted band size:30 KDa.Observed band size:30KDa.