Anti-SHANK3 mAb [S69-46]
產(chǎn)品名稱： Anti-SHANK3 mAb [S69-46]
英文名稱： SHANK3 Monoclonal Antibody [S69-46]
產(chǎn)品編號(hào)： SMC-336D
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 加拿大
品牌商標(biāo)： StressMarq
更新時(shí)間： null
使用范圍： WB, IHC, IP
StressMarq
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- 地址 : 加拿大
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Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SMC-336. Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (4). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (5). ?1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. www.iochannels.org
3. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.
4. Schuetz G., et al. (2004) JCB. 167(5): 645-952.
5. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27.