• 經測試應用IHC-Fr,?WB,?IHC-Pmore details
• 種屬反應性
  與反應:?Human
  預測可用于:?Mouse, Rat, Cow, Cat
• 免疫原

  Recombinant fragment: EVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS, corresponding to amino acids 158-350 of Human MVP (AAH15623)

  Run BLAST with??Run BLAST with?
• 陽性對照
  • 293T, A431, H1299, HeLa, HepG2, MOLT4, A549 and Raji cells

性能

• 形式Liquid
• 存放說明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存儲溶液Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• 濃度50 μl 濃度為 1 mg/ml?
  
• 純度Immunogen affinity purified
• 克隆多克隆
• 同種型IgG
• 研究領域
  • Signal Transduction
  ?
  • Protein Trafficking
  ?
  • Nuclear Import / Export

  • Cancer
  ?
  • Drug resistance
  ?
  • Vault proteins

應用

靶標

• 功能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
• 組織特異性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
• 序列相似性Contains 9 MVP (vault) repeats.
• 結構域MVP 3 mediates interaction with PTEN.
  MVP 4 mediates interaction with PARP4.
• 翻譯后修飾Phosphorylated on Tyr residues after EGF stimulation.
  Dephosphorylated by PTPN11.
• 細胞定位Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
• Information by UniProt
• 數據庫鏈接
  • Entrez Gene: 516456?Cow
  • Entrez Gene: 9961?Human
  • Entrez Gene: 78388?Mouse
  • Entrez Gene: 64681?Rat
  • Omim: 605088?Human
  • SwissProt: Q3SYU9?Cow
  • SwissProt: Q14764?Human
  • SwissProt: Q9EQK5?Mouse

  see all
• 別名
  • LRP antibody
  • Lung resistance related protein antibody
  • Lung resistance-related protein antibody

  see all

Anti-MVP antibody 圖像

• 

  Western blot - MVP antibody (ab97311)
  Anti-MVP antibody (ab97311) at 1/1000 dilution + MOLT4 whole cell lysate at 30 μg
  
  Predicted band size :?99 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MVP antibody (ab97311)