Product: Anti-Cholesteryl Ester Transfer Protein (CETP) pAb
Cat. No.: PC-355 (100 μg)
Background:
It has been proposed that high-density
lipoproteins (HDLs) function jointly with lecithin:
cholesterol acyltransferase and CETP to
facilitate cholesterol transport from tissues to the
liver. This mechanism, referred to as reverse
cholesterol transport, is physiologically important
because it maintains systemic cholesterol levels.
CETP is responsible for neutral lipid transfer
activity in plasma in numerous species. Since
CETP is able to accelerate specifically the
exchange of lipid components between pro- and
anti-atherogenic lipoprotein fractions, it may be a
key determinant of the global atherogenicity of
the plasma lipoprotein profile and arises as a
possible target in atherosclerosis prevention.
CETP has an important role in reverse
cholesterol transport and shaping and affecting
the composition of plasma lipoproteins. In
general elevated levels of CETP have been
associated with increased risk of coronary heart
disease.
Host:
Rabbit
Immunogen:
Synthetic peptide corresponding to the Cterminus
of human CETP.
Specificity:
Recognizes 70 kDa CETP protein of human and
rat origins.
Species Reactivity:
Human, mouse, rat and rabbit. Others not tested.
Format:
200 μL of 0.5 mg/mL peptide affinity-purified
rabbit polyclonal antibody in phosphate buffered
saline (PBS) containing 50% glycerol, 0.02%
sodium azide and protein stabilizer.
Storage:
Store at -20°C. For long term storage, aliquot
and store at -70°C. Avoid repeated freeze/thaw
cycles.
Applications and Suggested Dilutions:

Western blot: Use at 1-4 μg/mL.
The optimal dilution for a specific application
should be determined by the researcher.
Figure: Western blot analysis of CETP expression in rabbit
liver tissue lysate.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.