異染色質(zhì)蛋白1-γ/HP-1γ單克隆抗體
產(chǎn)品名稱： 異染色質(zhì)蛋白1-γ/HP-1γ單克隆抗體
英文名稱： HP1 gamma
產(chǎn)品編號： 52392R
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 上海
品牌商標： 雅吉
更新時間： null
使用范圍： WB, IF, ICC
上海雅吉生物科技有限公司
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?英文名稱HP1 gamma中文名稱異染色質(zhì)蛋白1-γ/HP-1γ單克隆抗體別? ? 名CBX 3; CBX3; Chromobox homolog 3; Chromobox protein homolog 3; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; HP1 gamma homolog; HP1Hs gamma ; Modifier 2; protein HP1-GAMMA; HP1g; M32; MGC118084; CBX3_HUMAN; Modifier 2 protein;? ?研究領(lǐng)域腫瘤? 細胞生物? 染色質(zhì)和核信號??抗體來源Mouse克隆類型Monoclonal克 隆 號5B9交叉反應Human, Mouse, Rat,?產(chǎn)品應用ELISA=1:1000-5000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分 子 量21kDa細胞定位細胞核?性? ? 狀Liquid濃? ? 度1mg/ml免 疫 原Recombinant human HP1 gamma Protein:?亞? ? 型IgG純化方法affinity purified by Protein G儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed產(chǎn)品介紹HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.?Function:Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.?Subunit:Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.?Subcellular Location:Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).?Post-translational modifications:Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.?Similarity:Contains 2 chromo domains.?SWISS:Q13185?Gene ID:11335?Database links:Entrez Gene: 11335 Human?Entrez Gene: 12417 Mouse?Entrez Gene: 297093 Rat?Omim: 604477 Human?SwissProt: Q13185 Human?SwissProt: P23198 Mouse?Unigene: 381189 Human?Unigene: 280968 Mouse?Unigene: 458234 Mouse?Unigene: 485141 Mouse????Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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