TIM-3/TIM3/TIMD3/FLJ14428/KIM3
產(chǎn)品名稱： TIM-3/TIM3/TIMD3/FLJ14428/KIM3
英文名稱： TIM-3/TIM3/TIMD3/FLJ14428/KIM3
產(chǎn)品編號(hào)： GMP-TL731
產(chǎn)品價(jià)格：
產(chǎn)品產(chǎn)地： China
品牌商標(biāo)： 同立海源生物
更新時(shí)間： 2023-08-22T16:18:28
使用范圍： null
| 規(guī)格 | 價(jià)格 |
| 100μg | 3000.0 |
- 聯(lián)系人 : 崔女士
- 地址 : 北京市大興區(qū)中關(guān)村科技園區(qū)大興生物醫(yī)藥產(chǎn)業(yè)基地華佗路50號(hào)院13號(hào)樓
- 郵編 : 100085
- 所在區(qū)域 : 北京
- 電話 : 186****3653 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : cuilimei@seafrom.cn
重組人TIM-3蛋白（Recombinant Human TIM-3 protein），GMP級(jí)
產(chǎn)品貨號(hào)：GMP-TL731
產(chǎn)品描述（Description）
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
分子別名（Synonym）
HAVCR2、TIM3、TIMD3、FLJ14428、KIM3
表達(dá)宿主（Expression host）
HEK293 細(xì)胞
來(lái)源（Source）
Human
蛋白序列（Protein Sequence）
DNA 序列編碼人 TIM3（ NCBI Reference Sequence:NP_116171.3）表達(dá)帶有 Fc 標(biāo)簽在 C 末端
分子量（Molecular Weight）
重組人 TIM-3 蛋白包含 412 個(gè)氨基酸，預(yù)測(cè)理論分子量為 49.5 kD
純度（Purity）
≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析
內(nèi)毒素（Endotoxin）
＜0.1EU/ug
生物活性 （Biological Activity）
固定人 TIM-3(Fc 標(biāo)簽)1ug/mL (100uL/孔) 能夠結(jié)合抗人 TIM-3 的抗體的線性范圍是 0.1-5ng/mL
組成（Component）
含有6%甘露醇的無(wú)菌PBS（PH 7.4）的凍干粉
穩(wěn)定性（Stability）
凍干的樣本的可以在4℃保存24個(gè)月，溶解后的液體可以于-20℃保存6-12個(gè)月，并且避免反復(fù)凍融
參考文獻(xiàn)
1、 Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines Feifei Pu, Fengxia Chen, Zhicai Zhang, Jing Feng, Ping Xia Future Sci OA. 2018 Jun; 4(5): FSO298. Published online 2018 Mar 15. doi: 10.4155/fsoa-2017-0121
2、 Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung CancerChih-Hsi Scott Kuo, Chien-Ying Liu, Stelios Pavlidis, Yu-Lun Lo, Yen-Wen Wang, Chih-Hung Chen, How-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Tsai-Yu Wang, Kang-Yun Lee, Yi-Ke Guo, Tzu-Hao Wang, Cheng-Ta Yang Front Immunol. 2018; 9: 232. Published online 2018 Feb 12. doi: 10.3389/fimmu.2018.00232
注意：For research and manufacturing use.