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Catalog Number:
AF-250-41
Description:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-3 is a 4.6 kDa protein containing 41 amino acid residues.
Manufactured using all Animal-Free reagents.
Source:
E.coli
Synonyms:
Beta-Defensin 3, DEFB3, DEFB103A
AA Sequence:
KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Not available.
Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.