Recombinant Human IL-36RA
Catalog Number:
200-36RA
Synonyms:
FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta
Description:
IL-1由11個結構上相關的配體組成，包括最近重新命名的IL-36RA（IL-1F5），IL-36α（IL-1F6），IL-36β（IL-1F8）和IL-36γ（IL-1F9）。IL-36的配體和IL-1Rrp2受體（IL-1R6）之間相互作用，可誘導多種生物學活性，包括樹突狀細胞的成熟和活化等。IL-36RA可通過與IL-1Rrp2受體結合、阻止功能信號的啟動，從而拮抗IL-36α，-β或-γ誘導的NF-κB信號通路。重組人IL-36RA由大腸桿菌表達的蛋白質，分子量為17 kDa，含有154個氨基酸殘基。
AA Sequence:
VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
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Research Interests:
Cancer
Diabetes / Weight Regulation
Immune System
Inflammation
Neurobiology
Proliferation
Wound Healing
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.