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Size??100ul
Cat code??220009
Species Cross-reactivity??H,Mk
Key Application??WB,ICC
Host??Mouse
Clone Number??7H10-B9-G5
Antibody type??Monoclonal antibody
Purified method??
Isotype??IgG1
Molecular Weight??33kDa
Sensitivity??The antibody detects endogenous level of total nucleophosmin.
Immunogen??Purified recombinant fragment of human NPM expressed in E. Coli.
UniProt Number??P06748
GeneBank ID??
Subcellular location??Nucleus ? nucleolus. Nucleus ? nucleoplasm. Cytoplasm ? cytoskeleton ? centrosome. Note: Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co-localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.
Formulation??Ascitic fluid containing 0.03% sodium azide.
Altername??B23 ;MGC104254 ;NMP1 ;NO38 ;NPM 1 ;NPM ;NPM_HUMAN ;NPM1 ;Nucleolar Phosphoprotein B23 ;Nucleolar protein NO38 ;Nucleophosmin (nucleolar phosphoprotein B23 numatrin) ;Nucleophosmin ;Nucleophosmin/B23.2 ;Nucleophosmin/nucleoplasmin family member 1 ;Nucleoplasmin Family Member 1 ;Numatrin ;OTTHUMP00000161024 ;OTTHUMP00000161025 ;OTTHUMP00000223397 ;OTTHUMP00000223398 ;TRK fused gene
Gene_symbol??B23; NPM
Summary??This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniPort summary  Function??Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Application Images :??
Western blot detection of NPM1 antibody in HaCat, COSY, 293, HepG2 and Hela cell lysates using NPM1 antibody(dilution 1:500).Predicted band size:33 KDa.Observed band size:33KDa.
Immunocytochemistry of HeLa cells using anti-NPM1 antibody diluted 1:100.