PeproTech大鼠抗小鼠CD357 (GITR) APC
產品名稱： PeproTech大鼠抗小鼠CD357 (GITR) APC
英文名稱： Anti-Mouse CD357 (AITR / GITR) APC
產品編號： 39612-80-100
產品價格： null
產品產地： USA
品牌商標： peperotech(BioGems)
更新時間： null
使用范圍： 流式
美國PeproTech(派普泰克)公司中國代表處
- 聯系人 :
- 地址 :  江蘇省蘇州市工業園區星湖街218號A1北座4樓L03
- 郵編 : 215123
- 所在區域 : 江蘇
- 電話 : 點擊查看
- 傳真 : 點擊查看
- 郵箱 : peprotech.infochina@thermofisher.com
The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in nave mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.