瑞博西尼 Ribociclib 1211441-98-3
產品名稱： 瑞博西尼 Ribociclib 1211441-98-3
英文名稱： Ribociclib
產品編號： 1211441-98-3
產品價格： 0
產品產地： 國外
品牌商標： MEDKOO
更新時間： null
使用范圍： null
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Description:?Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
CAS#: 1211441-98-3 (free base)
Chemical Formula: C23H30N8O
Exact Mass: 434.25426
Molecular Weight: 434.54
Elemental Analysis: C, 63.57; H, 6.96; N, 25.79; O, 3.68
Synonym:?LEE011; LEE-011. LEE 011; Ribociclib; Kisqali.
IUPAC/Chemical Name:?7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
InChi Key:?RHXHGRAEPCAFML-UHFFFAOYSA-N
InChi Code:?InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
SMILES Code:?O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C
Appearance:?Yellow solid powder
Purity:?>98% (or refer to the Certificate of Analysis)
Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:?Soluble in DMSO, not in water
Shelf Life:?>2 years if stored properly
Drug Formulation:?This drug may be formulated in DMSO
Stock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code:?2934.99.9001