MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Bicuculline methobromide

CAS No. : 66016-70-4

MCE 國際站：Bicuculline methobromide

產品活性：Bicuculline methobromide 是一種選擇性GABAA 受體 (GABAA Receptor) 拮抗劑，IC₅₀ 值為 3 μM。Bicuculline methobromide 在哺乳動物中可以誘導陣攣性強直性驚厥，還可用于阻斷 Ca²⁺ 激活的鉀通道。Bicuculline methobromide 可用于癲癇等相關精神疾病的研究。

研究領域：Membrane Transporter/Ion Channel??|??Neuronal Signaling

作用靶點：GABA Receptor

In Vitro: Bicuculline methobromide (1 μM and 3 μM) attains the maximal response of GABA. Bicuculline methobromide appears to shift the dose–response curves of GABA in parallel to the right without decreasing GABA maximal response, suggesting that it is a competitive antagonist at human α₁β₂γ_2L GABA_A receptors expressed in Xenopus oocytes.
Bicuculline methobromide (1-100 μM; 2 min; applied as outside-out patches) potently blocks both Apamin (HY-P0256)-sensitive small-conductance calcium-activated potassium channels (SK2) currents and Apamin-insensitive SK1 currents in Xenopus oocytes.

In Vivo: Bicuculline methobromide (subcutaneous injection, 1.25-3 mg/kg) can cause clonus-tonic convulsions in a dose-dependent manner in mice and these convulsions are enhanced by injection of the μ-opioid agonist morphine.
Bicuculline methobromide (subcutaneous injection, 1.5-3.2 mg/kg) induces male Swiss S mice generalized seizures with a CD₅₀ (convulsant dose) of 2.2 mg/kg for clonus and CD₅₀ of 2.4 mg/kg for tonus. Seizures induced by Bicuculline at the dose of 3.2 mg/kg can be blocked by pretreatment (i.p.) with the NMDA antagonists MK-801, CPP and CGS 19755.

相關產品：Bicuculline??|??γ-Aminobutyric acid??|??Picrotoxin??|??Propofol??|??Aminooxyacetic acid hemihydrochloride??|??Riluzole??|??Furosemide??|??Gabazine??|??Baclofen??|??Amentoflavone??|??WS6??|??Flumazenil??|??CGP52432??|??Vigabatrin??|??Methionine??|??Muscimol??|??THIP??|??Topiramate??|??L-Cycloserine??|??Tiagabine hydrochloride??|??Etiocholanolone??|??Jujuboside A??|??(S)-SNAP5114??|??Broflanilide??|??Ginsenoside Rc??|??Dihydroergotoxine mesylate??|??Emamectin Benzoate

熱門產品線：重組蛋白? |? 藥物篩選? |? 天然產物? |? 熒光染料? |? PROTAC? |? 同位素標記物

Trending products：Recombinant Proteins? |? Bioactive Screening Libraries? |? Natural Products? |? Dye Reagents? |? PROTAC? |? Isotope-Labeled Compounds

品牌介紹:
????MCE (MedChemExpress) 擁有200 多種全球獨家化合物庫，我們致力于為全球科研客戶提供前沿最全的高品質小分子活性化合物；
????50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領域；
????產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
????提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
????設有專業的實驗中心和嚴格的質控、驗證體系；
????提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
????產品的生物活性多經各國客戶實驗驗證；
????Nature, Cell, Science 等多種頂級期刊及制藥專利收錄了MCE客戶的科研成果；
????專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球最新的活性化合物；
????與世界各大制藥公司及知名科研機構建立了長期的合作。