KIR2DL4 monoclonal antibody, clone mAb#33
產品名稱： KIR2DL4 monoclonal antibody, clone mAb#33
英文名稱： KIR2DL4 monoclonal antibody, clone mAb#33
產品編號： MAB10178
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against KIR2DL4.
- Immunogen:
- NK3.3 cells and human KIR2DL4-Ig fusion protein.
- Host:
- Mouse
- Theoretical MW (kDa):
- 45
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (1 ug/ml)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Western Blot
- Immunocytochemistry
- Immunoprecipitation
- Functional Study
- Flow Cytometry
- Entrez GeneID:
- 3805
- Gene Name:
- KIR2DL4
- Gene Alias:
- CD158D,G9P,KIR103,KIR103AS
- Gene Description:
- killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
- Omim ID:
- 604945
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq
- Other Designations:
- NK cell receptor,OTTHUMP00000068610,natural killer cell inhibitory receptor
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Acute Disease
- Autoimmune Diseases
- Behcet Syndrome
- Carcinoma, Hepatocellular
- Cervical Intraepithelial Neoplasia
- Cytomegalovirus Infections
- Diabetes Mellitus, Type 1
- Disease Progression
- Familial Mediterranean Fever
- Familial Mediterranean fever
- Gastritis
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Hematologic Neoplasms
- Hemorrhagic Fever, Ebola
- Hepatitis B, Chronic
- Hepatitis C, Chronic