Anti-IDH1 Mouse Monoclonal Antibody-抗體-抗體-生物在線
武漢紐斯特生物技術有限公司
Anti-IDH1 Mouse Monoclonal Antibody

Anti-IDH1 Mouse Monoclonal Antibody

商家詢價

產品名稱： Anti-IDH1 Mouse Monoclonal Antibody

英文名稱： Anti-IDH1 Mouse Monoclonal Antibody

產品編號： 26136

產品價格： null

產品產地： 美國

品牌商標： NewEastbio

更新時間： null

使用范圍： ELISA, WB, IHC, IP

武漢紐斯特生物技術有限公司
  • 聯系人 :
  • 地址 : 武漢市東湖新技術開發區光谷生物城B3-3棟2-3樓
  • 郵編 : 430074
  • 所在區域 : 湖北
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  • 郵箱 : neweast3@126.com

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IDH1 [26136]
[100 μL]		 ?

Catalog Number:??26136
Gene Symbol:??IDH1
Description: ??Anti-IDH1 Mouse Monoclonal Antibody
Background: ??Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-132 in IDH to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
Immunogen: ??Recombinant proteins of human IDH1 (amino acids 1-240).
Applications: ??ELISA, WB, IHC, IP
Recommended Dilutions: ??
ELISA: 1:1000-1:5000
WB: 1:100-1:1000
IHC: 1:50-1:100
Concentration: ??1 mg/ml
Host: ??mouse
Format: ??Liquid
Clonality: ??Monoclonal
Isotype: ??IgG
Purity: ??Purified from ascites
Storage buffer:
Preservative:??no
Constituents:??PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:??Anti-IDH1 antibody recognizes IDH1 of vertebrates.
Storage Conditions:??Store at -20°C. Avoid freeze / thaw cycles
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Western blot:??
Western blot analysis of recombinant IDH1 protein. Purified His-tagged IDH1 protein (amino acids 1-240) (Cat.#10198) was blotted with anti-IDH1 mouse antibody (Cat.# 26136).
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Publications:
1.??Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
????Brain Tumor Pathology. January 2015, Volume 32, Issue 1, pp 3-11
2.??Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
????Nature 513, 110–114 (04 September 2014)
3.??Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism
????Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015