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Recombinant Human/Murine/Rat Activin A (CHO cell derived)
Catalog Number:
120-14P
Synonyms:
Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
Description:
Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellularproliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors andin postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin Acan be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activinreceptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins arehomodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptidethat is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
AA Sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
?Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected?ED50?is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105?units/mg.
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Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
Apoptosis
        
        

            

            
Cancer
            

            
Neurobiology
        
        

            

            
Stem Cells & Differentiation
            

            
TGF-β Superfamily
        
    


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Country of Origin:
USA